Virology
The virology group works with positive strand RNA viruses of the family Flaviviridae and Noroviruses.
Main focus of research are RNA replication, virion morphogenesis and virus-host interactions.
Fig.: BVDV NS5A-mCherry colocalizes
with Perilipin-GFP at lipid droplet surfaces
Cell Biology
The main focus in cell biology is the understanding of the subcellular structures supporting infection by human pathogenic viruses and of the interplay between the virus and the cell. We study how plus-strand RNA viruses „build a nest“ within the complex cell interior to multiply and how they hijack, reshuffle or create new compartments within the infected cell. The other way around, we investigate how the cell organizes its defense across its compartmentalized interior.
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