Publication List:
 

  1. EMILIN1 deficiency causes arterial tortuosity with osteopenia and connects impaired elastogenesis with defective collagen fibrillogenesis.
    Adamo CS, Beyens A, Schiavinato A, Keene DR, Tufa SF, Mörgelin M, Brinckmann J, Sasaki T, Niehoff A, Dreiner M, Pottie L, Muiño-Mosquera L, Gulec EY, Gezdirici A, Braghetta P, Bonaldo P, Wagener R, Paulsson M, Bornaun H, De Rycke R, De Bruyne M, Baeke F, Devine WP, Gangaram B, Tam A, Balasubramanian M, Ellard S, Moore S, Symoens S, Shen J, Cole S, Schwarze U, Holmes KW, Hayflick SJ, Wiszniewski W, Nampoothiri S, Davis EC, Sakai LY, Sengle G, Callewaert B. Am J Hum Genet. 2022 Nov 1:S0002-9297(22)00458-X.

  2. Copper-Binding Domain Variation in a Novel Murine Lysyl Oxidase Model Produces Structurally Inferior Aortic Elastic Fibers Whose Failure Is Modified by Age, Sex, and Blood Pressure.
    Tsang KM, Knutsen RH, Billington CJ Jr, Lindberg E, Steenbock H, Fu YP, Wardlaw-Pickett A, Liu D, Malide D, Yu ZX, Bleck CKE, Brinckmann J, Kozel BA. Int J Mol Sci. 2022 Jun 17;23(12):6749. doi: 10.3390/ijms23126749.

  3. Increased Fibrosis in a Mouse Model of Anti-Laminin 332 Mucous Membrane Pemphigoid Remains Unaltered by Inhibition of Aldehyde Dehydrogenase.
    Patzelt S, Pigors M, Steenbock H, Diel L, Boch K, Chakievska L, Künzel S, Busch H, Fähnrich A, Brinckmann J, Schmidt E. Front Immunol. 2022 Feb 7;12:812627.

  4. Mitochondrial respiratory chain function promotes extracellular matrix integrity in cartilage.
    Bubb K, Holzer T, Nolte JL, Krüger M, Wilson R, Schlötzer-Schrehardt U, Brinckmann J, Altmüller J, Aszodi A, Fleischhauer L, Clausen-Schaumann H, Probst K, Brachvogel B. J Biol Chem. 2021 Sep 21:101224. doi: 10.1016/j.jbc.2021.101224.

  5. Fibroblast MMP14-Dependent Collagen Processing Is Necessary for Melanoma Growth.
    Pach E, Brinckmann J, Rübsam M, Kümper M, Mauch C, Zigrino P. Cancers (Basel). 2021 Apr 20;13(8):1984. doi: 10.3390/cancers13081984.

  6. Increased volume and collagen crosslinks drive soft tissue contribution to post‐traumatic elbow contracture in an animal model.
    Dunham CL, Steenbock H, Brinckmann J, Reiter AJ, Castile RM, Chamberlain AM, Lake SP. J Orthop Res 2021 Aug;39(8):1800-1810 DOI: 10.1002/jor.24781

  7. A Dual-Acting Nitric Oxide Donor and Phosphodiesterase 5 Inhibitor Promotes Wound Healing in Normal Mice and Mice with Diabetes.
    Ben-Yehuda Greenwald M, Tacconi C, Jukic M, Joshi N, Hiebert P, Brinckmann J, Tenor H, Naef R, Werner S. J Invest Dermatol. 2021 141(2):415-426. doi: 10.1016/j.jid.2020.05.111

  8. Dysregulated assembly of elastic fibers in fibulin-5 knockout mice results in a tendon-specific increase in elastic modulus.
    Eekhoff JD, Steenbock H, Berke IM, Brinckmann J, Yanagisawa H, Wagenseil JE, Lake SP. J Mech Behav Biomed Mater. 2020 Oct 7;113:104134.doi: 10.1016/j.jmbbm.2020.104134

  9. Minoxidil cannot be used to target lysyl hydroxylases during post natal mouse lung development: a cautionary note.
    Pfeffer T, Lignelli E, Inoue H, Mižíková I, Surate Solaligue DE, Steenbock H, Myti D, Vadász I, Herold S, Brinckmann J, Seeger W, Morty RE. J Pharmacol Exp Ther. 2020 Oct 5:JPET-AR-2020-000138. doi: 10.1124/jpet.120.000138

  10. Role of collagen XII in skin homeostasis and repair.
    Schönborn K, Willenborg S, Schulz JN, Imhof T, Eming SA, Quondamatteo F, Brinckmann J, Niehoff A, Paulsson M, Koch M, Eckes B, Krieg T. Matrix Biol. 2020 Sep 2:S0945-053X(20)30087-1. doi: 10.1016/j.matbio.2020.08.002. Online ahead of print.

  11. Increased volume and collagen crosslinks drive soft tissue contribution to post‐traumatic elbow contracture in an animal model.
    Dunham CL, Steenbock H, Brinckmann J, Reiter AJ, Castile RM, Chamberlain AM, Lake SP. J Orthop Res DOI: 10.1002/jor.24781, 2020

  12. A Dual-Acting Nitric Oxide Donor and Phosphodiesterase 5 Inhibitor Promotes Wound Healing in Normal Mice and Mice with Diabetes.
    Ben-Yehuda Greenwald M, Tacconi C, Jukic M, Joshi N, Hiebert P, Brinckmann J, Tenor H, Naef R, Werner S. J Invest Dermatol. 2020 Jun 27:S0022-202X(20)31725-5. doi: 10.1016/j.jid.2020.05.111.

  13. Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds.
    Wietecha MS, Pensalfini M, Cangkrama M, Müller B, Jin J, Brinckmann J, Mazza E, Werner S. . Nat Commun. 2020 May 25;11(1):2604. doi: 10.1038/s41467-020-16409-z.

  14. Increased Collagen Turnover Impairs Tendon Microstructure and Stability in Integrin α2β1-Deficient Mice.
    Kronenberg D, Michel PA, Hochstrat E, Wei M, Brinckmann J, Müller M, Frank A, Hansen U, Eckes B, Stange R. Int J Mol Sci. 2020 Apr 18;21(8):2835. doi: 10.3390/ijms21082835.

  15. A comprehensive map of human elastin cross-linking during elastogenesis.
    Hedtke T, Schräder CU, Heinz A, Hoehenwarter W, Brinckmann J, Groth T, Schmelzer CEH.FEBS J. 2019 Sep;286(18):3594-3610. doi: 10.1111/febs.14929.

  16. Elastin is heterogeneously cross-linked.
    Schräder CU, Heinz A, Majovsky P, Karaman B, Brinckmann J, Sippl W, Schmelzer CEHJ Biol Chem. 2018 Aug 14. pii: jbc.RA118.004322. doi: 10.1074/jbc.RA118.004322

  17. Roles of fibronectin isoforms in neonatal vascular development and matrix integrity.
    Kumra H, Sabatier L, Hassan A, Sakai T, Mosher DF, Brinckmann J, Reinhardt DP. PLoS Biol. 2018 Jul 23;16(7):e2004812

  18. Nrf2-Mediated Fibroblast Reprogramming Drives Cellular Senescence by Targeting the Matrisome.
    Hiebert P, Wietecha MS, Cangkrama M, Haertel E, Mavrogonatou E, Stumpe M, Steenbock H, Grossi S, Beer HD, Angel P, Brinckmann J, Kletsas D, Dengjel J, Werner S Dev Cell. 2018 Jul 16;46(2):145-161

  19. Targeting transglutaminase 2 partially restores extracellular matrix structure but not alveolar architecture in experimental bronchopulmonary dysplasia.
    Mižíková I, Pfeffer T, Nardiello C, Surate Solaligue DE, Steenbock H, Tatsukawa H, Silva DM, Vadász I, Herold S, Pease RJ, Iismaa SE, Hitomi K, Seeger W, Brinckmann J, Morty RE. FEBS J. 2018 Jun 23. doi: 10.1111/febs.14596

  20. A type VII collagen subdomain mutant is thermolabile and shows enhanced proteolytic degradability - Implications for the pathogenesis of recessive dystrophic epidermolysis bullosa?
    Windler C, Hermsdorf U, Brinckmann J, Seeger K. Biochim Biophys Acta. 2017 Jan;1863(1):52-59

  21. The extracellular matrix signature in vein graft disease
    Birgit Kahle, Claudia Schmidtke, Nicolas Hunzelmann, Claus Bartels, Hans H. Sievers, Heiko Steenbock, Dieter P. Reinhardt, Jürgen Brinckmann.  Can J Cardiol. 2016 Aug;32(8):1008.e11-7

  22. Fibroblast-Derived MMP-14 Regulates Collagen Homeostasis in Adult Skin.
    Zigrino P, Brinckmann J, Niehoff A, Lu Y, Giebeler N, Eckes B, Kadler KE, Mauch C. J Invest Dermatol. 2016 J Invest Dermatol. 2016 Aug;136(8):1575-83

  23. COMP-assisted collagen secretion--a novel intracellular function required for fibrosis.
    Schulz JN, Nüchel J, Niehoff A, Bloch W, Schönborn K, Hayashi S, Kamper M, Brinckmann J, Plomann M, Paulsson M, Krieg T, Zaucke F, Eckes B. J Cell Sci. 2016 Feb 15;129(4):706-16. doi: 10.1242/jcs.180216

  24. Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair.
    Knipper JA, Willenborg S, Brinckmann J, Bloch W, Maaß T, Wagener R, Krieg T, Sutherland T, Munitz A, Rothenberg ME, Niehoff A, Richardson R, Hammerschmidt M, Allen JE, Eming SA.Immunity. 2015 Oct 20;43(4):803-16. doi: 10.1016/j.immuni.2015.09.005

  25. Collagen and elastin cross-linking is altered during aberrant late lung development associated with hyperoxia.
    Mižíková I, Ruiz-Camp J, Steenbock H, Madurga A, Vadász I, Herold S, Mayer K, Seeger W, Brinckmann J, Morty RE. Am J Physiol Lung Cell Mol Physiol. 2015 Jun 1;308(11):L1145-58

  26. Lysyl Oxidases Play a Causal Role in Vascular Remodeling in Clinical and Experimental Pulmonary Arterial Hypertension. 
    Nave AH, Mižíková I, Niess G, Steenbock H, Reichenberger F, Talavera ML, Veit F, Herold S, Mayer K, Vadász I, Weissmann N, Seeger W, Brinckmann J, Morty RE. Arterioscler Thromb Vasc Biol. 2014 May 15

  27. Genetic Ablation of Mast Cells Redefines the Role of Mast Cells in Skin Wound Healing and Bleomycin-Induced Fibrosis.
    Willenborg S, Eckes B, Brinckmann J, Krieg T, Waisman A, Hartmann K, Roers A, Eming SA. J Invest Dermatol. 2014 Jan 9

  28. TSG-6 released from intradermally injected mesenchymal stem cells accelerates wound healing and reduces tissue fibrosis in murine full-thickness skin wounds.
    Qi Y, Jiang D, Sindrilaru A, Stegemann A, Schatz S, Treiber N, Rojewski M, Schrezenmeier H, Vander Beken S, Wlaschek M, Böhm M, Seitz A, Scholz N, Dürselen L, Brinckmann J, Ignatius A, Scharffetter-Kochanek K.  J Invest Dermatol. 2014 Feb;134(2):526-37

  29. Elastin haploinsufficiency impedes the progression of arterial calcification in MGP-deficient mice. 
    Khavandgar Z, Roman H, Li J, Lee S, Vali H, Brinckmann J, Davis EC, Murshed M. J Bone Miner Res. 2014 Feb;29(2):327-37

  30. Influence of silicone gel on standardized postoperative scars.
    Riedel M, Brinckmann J, Steffen A, Nitsch S, Wollenberg B, Frenzel H. J Dtsch Dermatol Ges. 2013 May;11(5):412-9.

  31. Influence of compression therapy on expression of extracellular matrix proteins in chronic venous insufficiency of the lower leg. 
    Gerdes O., Brinckmann J, Zillikens D., Kahle B. Phlebologie 2012; 41 3: 121-127

  32. Elevated MMP-7 levels in patients with systemic sclerosis: correlation with pulmonary involvement. 
    Moinzadeh P, Krieg T, Hellmich M, Brinckmann J, Neumann E, Müller-Ladner U, Kreuter A, Dumitrescu D, Rosenkranz S, Hunzelmann N. Exp Dermatol. 2011; 20(9):770-3

  33. Enhanced fibrillin-2 expression is a general feature of wound healing and sclerosis: potential alteration of cell attachment and storage of TGF-beta.
    Brinckmann J, Hunzelmann N, Kahle B, Rohwedel J, Kramer J, Gibson MA, Hubmacher D, Reinhardt DP. Lab Invest. 2010, 90(5):739-52

  34. What are the new milestones in the pathogenesis of systemic sclerosis?Hunzelmann N, Brinckmann J. Ann Rheum Dis. 2010;69 Suppl 1:i52-56

  35. Alternate trafficking of cathepsin L in dermal fibroblasts induced by UVA radiation. 
    Klose A, Wilbrand-Hennes A, Brinckmann J, Hunzelmann N. Exp Dermatol. 2010 Aug;19(8):e117-23

  36. Immunophenotyping of the human bulge region: the quest to define useful in situ markers for human epithelial hair follicle stem cells and their niche. 
    Kloepper JE, Tiede S, Brinckmann J, Reinhardt DP, Faessler J, Paus R. Exp Dermatol 2008 Jul;17(7):592-609

  37. Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.
    El-Hallous E, Sasaki T, Hubmacher D, Getie M, Tiedemann K, Brinckmann J, Bätge B, Davis EC, Reinhardt DP. J Biol Chem. 2007 Mar 23;282(12):8935-46.

  38. Functional diversity of lysyl hydroxylase 2 in collagen synthesis of human dermal fibroblasts. 
    Wu J, Reinhardt DP, Batmunkh C, Lindenmaier W, Far RK, Notbohm H, Hunzelmann N, Brinckmann J. Exp Cell Res. 2006 Nov 1;312(18):3485-94.

  39. Absence of autoantibodies against correctly folded recombinant fibrillin-1 protein in systemic sclerosis patients. 
    Brinckmann J, Hunzelmann N, El-Hallous E, Krieg T, Sakai LY, Krengel S, Reinhardt DP. Arthritis Res Ther. 2005;7(6):R1221-6.

  40. Interleukin 4 and prolonged hypoxia induce a higher gene expression of lysyl hydroxylase 2 and an altered cross-link pattern: important pathogenetic steps in early and late stage of systemic scleroderma?
    Brinckmann J, Kim S, Wu J, Reinhardt DP, Batmunkh C, Metzen E, Notbohm H, Bank RA, Krieg T, Hunzelmann N. Matrix Biol. 2005 Oct;24(7):459-68.

  41. Modification of the structure and function of fibrillin-1 by homocysteine suggests a potential pathogenetic mechanism in homocystinuria.
    Hubmacher D, Tiedemann K, Bartels R, Brinckmann J, Vollbrandt T, Bätge B, Notbohm H, Reinhardt DP. J Biol Chem. 2005 Oct 14;280(41):34946-55.

  42. Collagen at a glance.
    Brinckmann J. Top Curr Chem 247:1-6

  43. Selective down-regulation of the alpha6-integrin subunit in melanocytes by UVB light.
    Krengel S, Stark I, Geuchen C, Knoppe B, Scheel G, Schlenke P, Gebert A, Wünsch L, Brinckmann J, Tronnier M. Exp Dermatol. 2005 Jun;14(6):411-9.

  44. Consequences of cysteine mutations in calcium-binding epidermal growth factor modules of fibrillin-1. 
    Vollbrandt T, Tiedemann K, El-Hallous E, Lin G, Brinckmann J, John H, Bätge B, Notbohm H, Reinhardt DP. J Biol Chem. 2004 Jul 30;279(31):32924-31.

  45. Ehlers-Danlos syndrome type VI with cystic malformations of the meninges in a 7-year-old girl. 
    Brunk I, Stöver B, Ikonomidou C, Brinckmann J, Neumann LM.  Eur J Pediatr. 2004 Apr;163(4-5):214-7.

  46. Changes in crosslinks in the collagenous connective tissue of lipodermatosclerosis.
    Gaber Y, Tiedemann K, Reinhard DP, Brinckmann J.  Phlebologie 33:8-11, 2004

  47. Reduced skin thickness: a new minor diagnostic criterion for the classical and hypermobility types of Ehlers-Danlos syndrome.
    Eisenbeiss C, Martinez A, Hagedorn-Greiwe M, Reinhardt DP, Bätge B, Brinckmann J. Br J Dermatol. 2003 Oct;149(4):850-2.

  48. Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis.
    van der Slot AJ, Zuurmond AM, Bardoel AF, Wijmenga C, Pruijs HE, Sillence DO, Brinckmann J, Abraham DJ, Black CM, Verzijl N, DeGroot J, Hanemaaijer R, TeKoppele JM, Huizinga TW, Bank RA.  J Biol Chem. 2003 Oct 17;278(42):40967-72.

  49. Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.
    Lin G, Tiedemann K, Vollbrandt T, Peters H, Batge B, Brinckmann J, Reinhardt DP.  J Biol Chem. 2002 Dec 27;277(52):50795-804.

  50. MMP-2, TIMP-2 and MT1-MMP are differentially expressed in lesional skin of melanocytic nevi and their expression is modulated by UVB-light. 
    Krengel S, Alexander M, Brinckmann J, Tronnier M. J Cutan Pathol. 2002

  51. Different pattern of collagen cross-links in two sclerotic skin diseases: lipodermatosclerosis and circumscribed scleroderma.
    Brinckmann J, Neess CM, Gaber Y, Sobhi H, Notbohm H, Hunzelmann N, Fietzek PP, Müller PK, Risteli J, Gebker R, Scharffetter-Kochanek K. J Invest Dermatol. 2001 Aug;117(2):269-73.

  52. UV light does not induce p53 mutation in melanocytes in vitro.  
    Tronnier M, Alexander M, Löntz W, Brinckmann J. Dermatology. 2001;202(4):339-40.

  53. Increased cell surface expression of receptors for transforming growth factor-beta on osteoblasts from patients with Osteogenesis imperfecta.
    Gebken J, Brenner R, Feydt A, Notbohm H, Brinckmann J, Müller PK, Bätge B. Pathobiology. 2000 May-Jun;68(3):106-12.

  54. [Morphological changes in melanocytic nevi induced by exogenous factors]
    Tronnier M, Alexander M, Neitmann M, Brinckmann J, Wolff HH. Hautarzt. 2000 Aug;51(8):561-6.

  55. Age-related differences in the expression of receptors for TGF-beta in human osteoblast-like cells in vitro.
    Bätge B, Feydt A, Gebken J, Klein H, Notbohm H, Müller PK, Brinckmann J. Exp Clin Endocrinol Diabetes. 2000;108(4):311-5.

  56. [Severe vitamin D deficiency osteomalacia by coincidence of multiple risk factors]
    Bätge B, Struck J, Klein HH, Brinckmann J.  Dtsch Med Wochenschr. 2000 Jun 16;125(24):761-5.

  57. Identification of a new heterozygous point mutation in the COL1A2 gene leading to skipping of exon 9 in a patient with joint laxity, hyperextensibility of skin and blue sclerae. Mutations in brief no. 166. Online.
    Feshchenko S, Brinckmann J, Lehmann HW, Koch HG, Müller PK, Kügler S. Hum Mutat. 1998;12(2):138.

  58. Attachment and chemotaxis of melanocytes after ultraviolet irradiation in vitro.
    Neitmann M, Alexander M, Brinckmann J, Schlenke P, Tronnier M.  Br J Dermatol. 1999 Nov;141(5):794-801

  59. Overhydroxylation of lysyl residues is the initial step for altered collagen cross-links and fibril architecture in fibrotic skin.
    Brinckmann J, Notbohm H, Tronnier M, Açil Y, Fietzek PP, Schmeller W, Müller PK, Bätge B.  J Invest Dermatol. 1999 Oct;113(4):617-21.

  60. Hypergravity stimulates collagen synthesis in human osteoblast-like cells: evidence for the involvement of p44/42 MAP-kinases (ERK 1/2). 
    Gebken J, Lüders B, Notbohm H, Klein HH, Brinckmann J, Müller PK, Bätge B. J Biochem. 1999 Oct;126(4):676-82.

  61. Ehlers-Danlos syndrome.
    Brinckmann J, Behrens P, Brenner R, Bätge B, Tronnier M, Wolff HH. Hautarzt. 1999 Apr;50(4):257-65.

  62. Ligand-induced downregulation of receptors for TGF-beta in human osteoblast-like cells from adult donors.
    Gebken J, Feydt A, Brinckmann J, Notbohm H, Müller PK, Bätge B. J Endocrinol. 1999 Jun;161(3):503-10.

  63. Ehlers-Danlos syndrome type VI: lysyl hydroxylase deficiency due to a novel point mutation (W612C).
    Brinckmann J, Açil Y, Feshchenko S, Katzer E, Brenner R, Kulozik A, Kügler S. Arch Dermatol Res. 1998 Apr;290(4):181-6.

  64. One single erythemagenic UV irradiation is more effective in increasing the proliferative activity of melanocytes in melanocytic naevi compared with fractionally applied high doses.
    Tronnier M, Rudolph P, Köser T, Raasch B, Brinckmann J. Br J Dermatol. 1997 Oct;137(4):534-9.

  65. Glycosylation of human bone collagen I in relation to lysylhydroxylation and fibril diameter.
    Bätge B, Winter C, Notbohm H, Acil Y, Brinckmann J, Müller PK. J Biochem. 1997 Jul;122(1):109-15.

  66. Semipreparative isolation of collagen types I, II, III and V by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and electroelution.
    Açil Y, Brinckmann J, Behrens P, Müller PK, Bätge B. J Chromatogr A. 1997 Jan 17;758(2):313-8.

  67. Altered x-ray diffraction pattern is accompanied by a change in the mode of cross-link formation in lipodermatosclerosis.
    Brinckmann J, Açil Y, Tronnier M, Notbohm H, Bätge B, Schmeller W, Koch MH, Müller PK, Wolff HH.  J Invest Dermatol. 1996 Oct;107(4):589-92.

  68. Changes with age in the urinary excretion of hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP). 
    Açil Y, Brinckmann J, Notbohm H, Müller PK, Bätge B.  Scand J Clin Lab Invest. 1996 May;56(3):275-83.

  69. Ehlers-Danlos syndrome type VI: cross-link pattern in tissue and urine sample as a diagnostic marker.
    Açil Y, Vetter U, Brenner R, Müller PK, Brinckmann J. J Am Acad Dermatol. 1995 Sep;33(3):522-4.

  70. Attachment of intrinsically and extrinsically aged fibroblasts on collagen and fibronectin. 
    Püschel HU, Chang J, Müller PK, Brinckmann J. J Photochem Photobiol B. 1995 Jan;27(1):39-46.

  71. Collagen synthesis in (sun-) aged human skin and in fibroblasts derived from sun-exposed and sun-protected body sites.
    Brinckmann J, Açil Y, Wolff HH, Müller PK. J Photochem Photobiol B. 1995 Jan;27(1):33-8.

  72. Analysis of the age-related composition of human skin collagen and collagens synthesized by fibroblast culture.
    Brinckmann J, Bodo M, Brey M, Wolff HH, Müller PK. Arch Dermatol Res. 1994;286(7):391-5.

  73. In vitro formation and aggregation of heterotypic collagen I and III fibrils. 
    Notbohm H, Mosler S, Müller PK, Brinckmann J. Int J Biol Macromol. 1993 Oct;15(5):299-304.

  74. Autoantibodies to cartilage collagens in relapsing polychondritis.
    Yang CL, Brinckmann J, Rui HF, Vehring KH, Lehmann H, Kekow J, Wolff HH, Gross WL, Müller PK. Arch Dermatol Res. 1993;285(5):245-9.

  75. [The synthesis of collagenous and noncollagenous proteins by cells from the periodontium] 
    Lang H, Schüler N, Zimmermann A, Bodo M, Brinckmann J, Mertens T, Müller PK, Nolden R. Dtsch Zahn Mund Kieferheilkd Zentralbl. 1992;80(6)