Publications (selection)

Tautz N, Meyers G, Thiel H-J. 1993. Processing of poly-ubiquitin in the polyprotein of an RNA virus. Virology. 197:74-85.

Tautz N, Thiel H-J, Dubovi E J, Meyers G. 1994. Pathogenesis of mucosal disease: a cytopathogenic pestivirus generated by internal deletion. J. Virol. 68:3289-3297.

Tautz N, Meyers G, Stark R, Dubovi E J, Thiel H-J. 1996. Cytopathogenicity of a pestivirus correlated with a 27 nucleotide insertion. J. Virol. 70:7851-7858.

Tautz N, Elbers K, Stoll D, Meyers G, Thiel H-J. 1997. Serine protease of pestiviruses: determination of cleavage sites. J. Virol. 71:5415-22.

Behrens S-E, Grassmann C W, Thiel H-J, Meyers G, Tautz N. 1998. Characterization of an autonomous subgenomic pestivirus RNA replicon. J. Virol. 72:2364-2372.

Tautz N, Harada T, Kaiser A, Rinck G, Behrens S-E, Thiel H-J. 1999. Establishment and characterization of cytopathogenic and noncytopathogenic pestivirus replicons. J. Virol. 73:9422-9432.

Tautz N, Kaiser A, Thiel H-J. 2000. NS3 serine protease of bovine viral diarrhea virus: Characterization of active site residues, NS4A cofactor domain, and protease-cofactor interactions. Virology 273:351-363.

Rinck G, Bighan C, Harada T, Meyers G, Thiel H-J, Tautz N. 2001. A cellular J-domain protein modulates polyprotein processing and cytopathogenicity of a pestivirus. J. Virol. 75: 9470-9482.

Müller A, Rinck G, Thiel H-J, Tautz N. 2003. Cell-derived sequences located in the structural genes of a cytopathogenic pestivirus. J. Virol. 77: 10663-10669.

Tautz N, Thiel H-J. 2003. Functional importance of the N terminus of NS3 for replication of pestiviruses. Arch. Virol. 148: 1405-12.

Lackner T, Müller A, Pankraz A, Becher P, Thiel H-J, Gorbalenya A E, Tautz N. 2004. Temporal modulation of an autoprotease is crucial for replication and pathogenicity of an RNA virus. J. Virol. 78:10765-10775.

Lackner T, Müller A, König M, Thiel H-J, Tautz N. 2005. Persistence of bovine viral diarrhea virus is determined by a cellular cofactor of a viral autoprotease. J. Virol. 79: 9746-9755.

Lackner T, Thiel H-J, Tautz N. 2006. Dissection of a viral autoprotease elucidates a function of a cellular chaperone in proteolysis. Proc. Natl. Acad. Sci. U S A. 103 (5): 1510-5.

Gallei A, Blome S, Gilgenbach S, Tautz N, Moennig V, Becher P. 2008. Cytopathogenicity of classical Swine Fever virus correlates with attenuation in the natural host. J. Virol. 82: 9717-9729.

Isken O, Kim YK, Hosoda N, Mayeur GL, Hershey JW, Maquat LE. 2008. Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay. Cell 133:314-27.

Isken O, Maquat LE. 2008. The multiple lives of NMD factors: balancing roles in gene and genome regulation. Nat Rev Genet. 2008. 9:699-712.

Schregel V, Jacobi S, Penin F and Tautz N. 2009. Hepatitis C virus NS2-3 protease - NS2 is a bona fide protease stimulated by cofactor domains in NS3. Proc. Natl. Acad. Sci. USA 106: 5342-7.

Ciesek S, Steinmann E, Wedemeyer H, Manns MP, Neyts J, Tautz N, Madan V, Bartenschlager R, von Hahn T, and Pietschmann T. 2009. Cyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin A. Hepatology. 50(5):1638-45.

Maquat LE, Tarn WY, Isken O. 2010. The pioneer round of translation: features and functions. Cell, Aug 6, 142 (3):368-74.

Pawlotsky JM, Cocquerel L, Durantel D, Lavillette D, Lerat H, Pécheur EI, Polyak SJ, Tautz N, and Thimme R. 2010. HCV Research 20 Years After Discovery: A Summary of the 16th International Symposium on Hepatitis C Virus and Related Viruses. Gastroenterology 138(1):6-12.

Tautz N and Meyers G. 2010. Basic science paves the way to novel safe and effective pestivirus vaccines, pp 173-193 in: Replicating Vaccines - A New Generation by Dormitzer PR, Mandl CW, Rappuoli R (Editors). Springer Basel AG 2011.

Becher P and Tautz N. 2011. RNA recombination in pestiviruses - cellular RNA sequences in viral genomes highlight the role of host factors for viral persistence and lethal disease. RNA Biol 8:216-24.

Lattwein E, Klemens O, Schwindt S, Becher P, Tautz N. 2012 Pestivirus virion morphogenesis in the absence of uncleaved nonstructural protein 2-3. Journal of virology 86:427-37.

 

Übersichtsartikel und Buchbeiträge

Tautz N, Thiel H-J. 2004. Pestivirus NS2-3/NS3 serine peptidase. In A.J. Barrett an N. D. Rawlings and J.F. Woessner (ed.), Handbook of proteolytic enzymes. Second Edition. Academic Press, p. 1781-1784.

Tautz N, Thiel H-J. Molekulare Pathogenese der Mucosal Disease. Nova Acta Leopoldina N. F. Bd. 94, Nr. 353. Zur Rolle der Veterinärmedizin in Forschung und Gesellschaft. Herausgegeben von Hartwig Bostedt (Gießen), Leo Brunnberg (Berlin), Johannes Eckert (Zürich), Theodor Hiepe (Berlin) und Holger Martens (Berlin). Symposium der Deutschen Akademie der Naturforscher und der Veterinärmedizinischen Gesellschaft am 13. und 14. Oktober 2006 in Berlin.