Publication List:

  1. Lysyl Oxidases Play a Causal Role in Vascular Remodeling in Clinical and Experimental Pulmonary Arterial Hypertension. 
    Nave AH, Mižíková I, Niess G, Steenbock H, Reichenberger F, Talavera ML, Veit F, Herold S, Mayer K, Vadász I, Weissmann N, Seeger W, Brinckmann J, Morty RE. Arterioscler Thromb Vasc Biol. 2014 May 15

  1. Genetic Ablation of Mast Cells Redefines the Role of Mast Cells in Skin Wound Healing and Bleomycin-Induced Fibrosis.
    Willenborg S, Eckes B, Brinckmann J, Krieg T, Waisman A, Hartmann K, Roers A, Eming SA. 
    J Invest Dermatol. 2014 Jan 9

  1. TSG-6 released from intradermally injected mesenchymal stem cells accelerates wound healing and reduces tissue fibrosis in murine full-thickness skin wounds.
    Qi Y, Jiang D, Sindrilaru A, Stegemann A, Schatz S, Treiber N, Rojewski M, Schrezenmeier H, Vander Beken S, Wlaschek M, Böhm M, Seitz A, Scholz N, Dürselen L, Brinckmann J, Ignatius A, Scharffetter-Kochanek K.  J Invest Dermatol. 2014 Feb;134(2):526-37

  1. Elastin haploinsufficiency impedes the progression of arterial calcification in MGP-deficient mice. 
    Khavandgar Z, Roman H, Li J, Lee S, Vali H, Brinckmann J, Davis EC, Murshed M. J Bone Miner Res. 2014 Feb;29(2):327-37

  1. Influence of silicone gel on standardized postoperative scars.
    Riedel M, Brinckmann J, Steffen A, Nitsch S, Wollenberg B, Frenzel H.
     J Dtsch Dermatol Ges. 2013 May;11(5):412-9.

  1. Influence of compression therapy on expression of extracellular matrix proteins in chronic venous insufficiency of the lower leg. 
    Gerdes O., Brinckmann J, Zillikens D., Kahle B.
    Phlebologie 2012; 41 3: 121-127

  1. Elevated MMP-7 levels in patients with systemic sclerosis: correlation with pulmonary involvement. 
    Moinzadeh P, Krieg T, Hellmich M, Brinckmann J, Neumann E, Müller-Ladner U, Kreuter A, Dumitrescu D, Rosenkranz S, Hunzelmann N.
    Exp Dermatol. 2011; 20(9):770-3

  1. Enhanced fibrillin-2 expression is a general feature of wound healing and sclerosis: potential alteration of cell attachment and storage of TGF-beta.
    Brinckmann J, Hunzelmann N, Kahle B, Rohwedel J, Kramer J, Gibson MA, Hubmacher D, Reinhardt DP. 
    Lab Invest. 2010, 90(5):739-52

  1. What are the new milestones in the pathogenesis of systemic sclerosis?Hunzelmann N, Brinckmann J. Ann Rheum Dis. 2010;69 Suppl 1:i52-56

  1. Alternate trafficking of cathepsin L in dermal fibroblasts induced by UVA radiation. 
    Klose A, Wilbrand-Hennes A, Brinckmann J, Hunzelmann N. Exp Dermatol. 2010 Aug;19(8):e117-23

  1. Immunophenotyping of the human bulge region: the quest to define useful in situ markers for human epithelial hair follicle stem cells and their niche. 
    Kloepper JE, Tiede S, Brinckmann J, Reinhardt DP, Faessler J, Paus R.
    Exp Dermatol 2008 Jul;17(7):592-609

  1. Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.
    El-Hallous E, Sasaki T, Hubmacher D, Getie M, Tiedemann K, Brinckmann J, Bätge B, Davis EC, Reinhardt DP. J Biol Chem. 2007 Mar 23;282(12):8935-46.

  1. Functional diversity of lysyl hydroxylase 2 in collagen synthesis of human dermal fibroblasts. 
    Wu J, Reinhardt DP, Batmunkh C, Lindenmaier W, Far RK, Notbohm H, Hunzelmann N, Brinckmann J. Exp Cell Res. 2006 Nov 1;312(18):3485-94.

  1. Absence of autoantibodies against correctly folded recombinant fibrillin-1 protein in systemic sclerosis patients. 
    Brinckmann J, Hunzelmann N, El-Hallous E, Krieg T, Sakai LY, Krengel S, Reinhardt DP. Arthritis Res Ther. 2005;7(6):R1221-6.

  1. Interleukin 4 and prolonged hypoxia induce a higher gene expression of lysyl hydroxylase 2 and an altered cross-link pattern: important pathogenetic steps in early and late stage of systemic scleroderma?
    Brinckmann J, Kim S, Wu J, Reinhardt DP, Batmunkh C, Metzen E, Notbohm H, Bank RA, Krieg T, Hunzelmann N. Matrix Biol. 2005 Oct;24(7):459-68.

  1. Modification of the structure and function of fibrillin-1 by homocysteine suggests a potential pathogenetic mechanism in homocystinuria.
    Hubmacher D, Tiedemann K, Bartels R, Brinckmann J, Vollbrandt T, Bätge B, Notbohm H, Reinhardt DP. J Biol Chem. 2005 Oct 14;280(41):34946-55.

  1. Collagen at a glance.
    Brinckmann J. Top Curr Chem 247:1-6

  1. Selective down-regulation of the alpha6-integrin subunit in melanocytes by UVB light.
    Krengel S, Stark I, Geuchen C, Knoppe B, Scheel G, Schlenke P, Gebert A, Wünsch L, Brinckmann J, Tronnier M. Exp Dermatol. 2005 Jun;14(6):411-9.

  1. Consequences of cysteine mutations in calcium-binding epidermal growth factor modules of fibrillin-1. 
    Vollbrandt T, Tiedemann K, El-Hallous E, Lin G, Brinckmann J, John H, Bätge B, Notbohm H, Reinhardt DP. J Biol Chem. 2004 Jul 30;279(31):32924-31.

  1. Ehlers-Danlos syndrome type VI with cystic malformations of the meninges in a 7-year-old girl. 
    Brunk I, Stöver B, Ikonomidou C, Brinckmann J, Neumann LM.
     Eur J Pediatr. 2004 Apr;163(4-5):214-7.

  1. Changes in crosslinks in the collagenous connective tissue of lipodermatosclerosis.
    Gaber Y, Tiedemann K, Reinhard DP, Brinckmann J.  Phlebologie 33:8-11, 2004

  1. Reduced skin thickness: a new minor diagnostic criterion for the classical and hypermobility types of Ehlers-Danlos syndrome.
    Eisenbeiss C, Martinez A, Hagedorn-Greiwe M, Reinhardt DP, Bätge B, Brinckmann J. Br J Dermatol. 2003 Oct;149(4):850-2.

  1. Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis.
    van der Slot AJ, Zuurmond AM, Bardoel AF, Wijmenga C, Pruijs HE, Sillence DO, Brinckmann J, Abraham DJ, Black CM, Verzijl N, DeGroot J, Hanemaaijer R, TeKoppele JM, Huizinga TW, Bank RA.  J Biol Chem. 2003 Oct 17;278(42):40967-72.

  1. Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.
    Lin G, Tiedemann K, Vollbrandt T, Peters H, Batge B, Brinckmann J, Reinhardt DP.  J Biol Chem. 2002 Dec 27;277(52):50795-804.

  1. MMP-2, TIMP-2 and MT1-MMP are differentially expressed in lesional skin of melanocytic nevi and their expression is modulated by UVB-light. 
    Krengel S, Alexander M, Brinckmann J, Tronnier M. J Cutan Pathol. 2002

  1. Different pattern of collagen cross-links in two sclerotic skin diseases: lipodermatosclerosis and circumscribed scleroderma.
    Brinckmann J, Neess CM, Gaber Y, Sobhi H, Notbohm H, Hunzelmann N, Fietzek PP, Müller PK, Risteli J, Gebker R, Scharffetter-Kochanek K. J Invest Dermatol. 2001 Aug;117(2):269-73.

  1. UV light does not induce p53 mutation in melanocytes in vitro.  
    Tronnier M, Alexander M, Löntz W, Brinckmann J. Dermatology. 2001;202(4):339-40.

  1. Increased cell surface expression of receptors for transforming growth factor-beta on osteoblasts from patients with Osteogenesis imperfecta.
    Gebken J, Brenner R, Feydt A, Notbohm H, Brinckmann J, Müller PK, Bätge B. Pathobiology. 2000 May-Jun;68(3):106-12.

  1. [Morphological changes in melanocytic nevi induced by exogenous factors]
    Tronnier M, Alexander M, Neitmann M, Brinckmann J, Wolff HH. Hautarzt. 2000 Aug;51(8):561-6.

  1. Age-related differences in the expression of receptors for TGF-beta in human osteoblast-like cells in vitro.
    Bätge B, Feydt A, Gebken J, Klein H, Notbohm H, Müller PK, Brinckmann J. Exp Clin Endocrinol Diabetes. 2000;108(4):311-5.

  1. [Severe vitamin D deficiency osteomalacia by coincidence of multiple risk factors]
    Bätge B, Struck J, Klein HH, Brinckmann J.  Dtsch Med Wochenschr. 2000 Jun 16;125(24):761-5.

  1. Identification of a new heterozygous point mutation in the COL1A2 gene leading to skipping of exon 9 in a patient with joint laxity, hyperextensibility of skin and blue sclerae. Mutations in brief no. 166. Online.
    Feshchenko S, Brinckmann J, Lehmann HW, Koch HG, Müller PK, Kügler S. Hum Mutat. 1998;12(2):138.

  1. Attachment and chemotaxis of melanocytes after ultraviolet irradiation in vitro.
    Neitmann M, Alexander M, Brinckmann J, Schlenke P, Tronnier M.  Br J Dermatol. 1999 Nov;141(5):794-801

  1. Overhydroxylation of lysyl residues is the initial step for altered collagen cross-links and fibril architecture in fibrotic skin.
    Brinckmann J, Notbohm H, Tronnier M, Açil Y, Fietzek PP, Schmeller W, Müller PK, Bätge B.  J Invest Dermatol. 1999 Oct;113(4):617-21.

  1. Hypergravity stimulates collagen synthesis in human osteoblast-like cells: evidence for the involvement of p44/42 MAP-kinases (ERK 1/2). 
    Gebken J, Lüders B, Notbohm H, Klein HH, Brinckmann J, Müller PK, Bätge B. J Biochem. 1999 Oct;126(4):676-82.

  1. Ehlers-Danlos syndrome.
    Brinckmann J, Behrens P, Brenner R, Bätge B, Tronnier M, Wolff HH. Hautarzt. 1999 Apr;50(4):257-65.

  1. Ligand-induced downregulation of receptors for TGF-beta in human osteoblast-like cells from adult donors.
    Gebken J, Feydt A, Brinckmann J, Notbohm H, Müller PK, Bätge B. J Endocrinol. 1999 Jun;161(3):503-10.

  1. Ehlers-Danlos syndrome type VI: lysyl hydroxylase deficiency due to a novel point mutation (W612C).
    Brinckmann J, Açil Y, Feshchenko S, Katzer E, Brenner R, Kulozik A, Kügler S. 
    Arch Dermatol Res. 1998 Apr;290(4):181-6.

  1. One single erythemagenic UV irradiation is more effective in increasing the proliferative activity of melanocytes in melanocytic naevi compared with fractionally applied high doses.
    Tronnier M, Rudolph P, Köser T, Raasch B, Brinckmann J.
    Br J Dermatol. 1997 Oct;137(4):534-9.

  1. Glycosylation of human bone collagen I in relation to lysylhydroxylation and fibril diameter.
    Bätge B, Winter C, Notbohm H, Acil Y, Brinckmann J, Müller PK.
     J Biochem. 1997 Jul;122(1):109-15.

  1. Semipreparative isolation of collagen types I, II, III and V by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and electroelution.
    Açil Y, Brinckmann J, Behrens P, Müller PK, Bätge B. J Chromatogr A. 1997 Jan 17;758(2):313-8.

  1. Altered x-ray diffraction pattern is accompanied by a change in the mode of cross-link formation in lipodermatosclerosis.
    Brinckmann J, Açil Y, Tronnier M, Notbohm H, Bätge B, Schmeller W, Koch MH, Müller PK, Wolff HH.  J Invest Dermatol. 1996 Oct;107(4):589-92.

  1. Changes with age in the urinary excretion of hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP). 
    Açil Y, Brinckmann J, Notbohm H, Müller PK, Bätge B.  Scand J Clin Lab Invest. 1996 May;56(3):275-83.

  1. Ehlers-Danlos syndrome type VI: cross-link pattern in tissue and urine sample as a diagnostic marker.
    Açil Y, Vetter U, Brenner R, Müller PK, Brinckmann J. J Am Acad Dermatol. 1995 Sep;33(3):522-4.

  1. Attachment of intrinsically and extrinsically aged fibroblasts on collagen and fibronectin. 
    Püschel HU, Chang J, Müller PK, Brinckmann J. J Photochem Photobiol B. 1995 Jan;27(1):39-46.

  1. Collagen synthesis in (sun-) aged human skin and in fibroblasts derived from sun-exposed and sun-protected body sites.
    Brinckmann J, Açil Y, Wolff HH, Müller PK. J Photochem Photobiol B. 1995 Jan;27(1):33-8.

  1. Analysis of the age-related composition of human skin collagen and collagens synthesized by fibroblast culture.
    Brinckmann J, Bodo M, Brey M, Wolff HH, Müller PK. Arch Dermatol Res. 1994;286(7):391-5.

  1. In vitro formation and aggregation of heterotypic collagen I and III fibrils. 
    Notbohm H, Mosler S, Müller PK, Brinckmann J. Int J Biol Macromol. 1993 Oct;15(5):299-304.

  1. Autoantibodies to cartilage collagens in relapsing polychondritis.
    Yang CL, Brinckmann J, Rui HF, Vehring KH, Lehmann H, Kekow J, Wolff HH, Gross WL, Müller PK. Arch Dermatol Res. 1993;285(5):245-9.

  1. [The synthesis of collagenous and noncollagenous proteins by cells from the periodontium] 
    Lang H, Schüler N, Zimmermann A, Bodo M, Brinckmann J, Mertens T, Müller PK, Nolden R. Dtsch Zahn Mund Kieferheilkd Zentralbl.
    1992;80(6)